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Unité de Formation et de Recherche de Chimie

"Mechanisms of Zinc Metallostasis in Bacterial Pathogens" 2018, June 22nd

David Giedroc Department of Chemistry, Indiana University,USA

PSL-BIC Program 2018

Room E012, salle des éléments, département de chimie de l’ENS, 24 rue Lhomond, 16h30


"Mechanisms of Zinc Metallostasis in Bacterial Pathogens"

First-row late d-block transition metals from Mn to Zn play critical and distinct roles in many aspects of cellular metabolism. In bacterial pathogens, metalloregulation of transcription underscores physiological adaptation to host-mediated transition metal starvation and toxicity, required to maintain metal homeostasis (metallostasis). Recent efforts to understand allostery in Zn-regulated repressors using NMR spectroscopy and companion biophysical methods, will be presented primarily focused in the Zn efflux regulator from Staphylococcus aureus, CzrA, and a Zn uptake regulator adhesin-competence repressor (AdcR) from the Gram-positive respiratory pathogen, Streptococcus pneumoniae.


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