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Unité de Formation et de Recherche de Chimie

" Platforms for the generation and high-throughput screening of SICLOPPS cyclic peptide libraries " Monday October 8th 2018



Ali Tavassoli (a.tavassoli @

(University of Southampton) 


Abstract :

Cyclic peptide libraries have demonstrated significant potential when employed against challenging targets such as protein– protein interactions. SICLOPPS is a method for the intracellular generation of cyclic peptide libraries of over a hundred million members. We have interfaced SICLOPPS libraries with a variety of cell-based assays for the identification of inhibitors of a variety of targets.  

The discovery and development of our cyclic peptide HIF-1 inhibitors will be discussed, along with details of a newly developed ultra-high throughput screening platform that allows the generation of SICLOPPS cyclic peptide libraries in femtolitre-sized microfluidic droplets.


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