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Unité de Formation et de Recherche de Chimie
UFR926

" From antibodies to MOFs: a full set of envelopes for metal cofactors in order to build up new artificial metalloenzymes " Monday January 13th

Jean-Pierre MAHY

 

(Paris-Saclay University)

jean-pierre.mahy @ u-psud.fr 

"From antibodies to MOFs: a full set of envelopes for metal cofactors in order to build up new artificial metalloenzymes"  

Abstract:

Our group has long been involved in the production of artificial Metalloenzymes that have been found able to catalyze stereo-selective oxidation of chemicals by H2O2, RNAse like hydrolysis of oligonucleotides and stereoselective Diels-Alder reactions. The most recent developments of our research will be presented here: 

- The design of new artificial metalloenzymes that catalyze the stereoselective Diels-Alder reaction “in vivo”.The use of such biocatalysts for theranostic purposes will be introduced. 

- The elaboration of totally artificial metalloenzymes by:  

(i) insertion of metal complexes into a new family of artificial proteins based on a thermostable alpha-helical repeated motif (αRep),  

(ii) insertion of a minienzyme, microperoxidase, into Metal Organic Frameworks (MOF), 

(iii) association of polyoxometallates (POMs) with artificial polyimine polymer-basedreductases, to afford ArMs that catalyze the oxidation of organic substrates by O2 in water.

27/01/20

Traductions :

    2019

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