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Unité de Formation et de Recherche de Chimie
UFR926

"Dienals as versatile substrates for the stereoselective synthesis of polycyclic architectures" Monday November 19th 2018

Xavier Moreau (xavier.moreau @ uvsq.fr)

 

(Université de Versailles Saint-Quentin-en-Yvelines) 

 

Abstract :

Polycyclicarchitecturesencompass a broadrangeofnatural and biologically relevant products. The vastarrayofstructuraldiversity and complexityreachedbythesemoleculeshasfascinatedsyntheticorganicchemistsovertheyears. Withinthecontextof total synthesisorsyntheticchemistrymethodology, considerableendeavorshavebeendevotedtothe design ofefficientdominotransformationsthatgenerateelaboratedpolycyclictridimentionalscaffoldsbearing multiple stereogeniccenters. Beyondthat, diversity-orientedsynthesis (DOS) basedaroundreadilyavailable and versatile startingmaterialsisoneofthemostattractivestrategytoachieveskeletaldiversity. Thus, mergingdominopolycyclizationswith DOS approachcouldleadtointricatesmall-moleculelibraries. In thiscontext, ourcurrentinterest in designingnewmethodologiestoaffordfunctionalizedpolycyclicscaffoldsfrom simple unsaturedaldehydes will bepresented.

15/11/18

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