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Unité de Formation et de Recherche de Chimie

" Heterocycles from the sea, a light from the abyss " Monday September 10th 2018

Yves L. Janin

(CNRS-Institut Pasteur)

Abstract :

A growing proportion of bioluminescent reporting systems are using imidazo[1,2-a]pyrazine luciferins such as the natural product coelenterazine or the analog furimazine along with photoproteins or luciferases from sea creatures. Our contribution has led to an original (gram-scale) synthesis of this heterocyclic system, the preparation of close to 150 analogues and thus to extensive insights in the structure-bioluminescence relationship when using NanoLuc/nanoKaz as the luciferase. 

Yves L. Janin (yves.janin @

(CNRS-Institut Pasteur)





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