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Unité de Formation et de Recherche de Chimie
UFR926

"Iodine(III)-Mediated Halogenation Reactions & Ynamides as Ketenimines Precursors" Monday January 14th 2018

 

 

Kevin CARIOU

(CNRS- Institut de Chimie de Substances Naturelles)

 

Monday January 14th

T 54-55 room 125, 11h

 

Abstract :

  In our group we develop synthetic methodologies that enable the construction of original molecular scaffolds possessing interesting biological properties. In particular, we try to bypass the use of unstable yet reactive intermediates by generating these species in situ. We pursue two lines of research in this direction, one deals with hypervalent iodine reagents and the second with the chemistry of ynamides. We use the former as mediators to trigger chemoselective halogenation reactions through the mild oxidation of halides. The latter are employed as readily available and stable precursors for the generation of ketenimines, which then undergo cycloaddition reactions. 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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Kevin CARIOU (CNRS- Institut de Chimie de Substances Naturelles)

kevin.cariou @ cnrs.fr

Iodine(III)-Mediated Halogenation Reactions & Ynamides as Ketenimines Precursors

Abstract.  In our group we develop synthetic methodologies that enable the construction of original molecular scaffolds possessing interesting biological properties. In particular, we try to bypass the use of unstable yet reactive intermediates by generating these species in situ. We pursue two lines of research in this direction, one deals with hypervalent iodine reagents and the second with the chemistry of ynamides. We use the former as mediators to trigger chemoselective halogenation reactions through the mild oxidation of halides. The latter are employed as readily available and stable precursors for the generation of ketenimines, which then undergo cycloaddition reactions.

 

10/01/19

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